Status: Completed

Start date: 1 June 2007

Completion date: 26 October 2017

Project code: N/A

Species: European foxes, Wild dogs

Summary

This project tested the safety and efficacy of the glovebox formulation of a methylene blue antidote to reduce PAPP toxicosis and revive an affected animal (i.e. working or pet dog).

Results from these trials showed that these formulations were not effective in reducing PAPP toxicosis, and as such the antidote is still only available as an intravenous administration by a veterinary practitioner.

Key achievements

Outputs

  • Testing of multiple pathways completed, no current viable and safe alternative to the vet-only intravenous administration route – as below.
    Delivery mode and pathway:
    Powder (aqueous): Not effective (oral and anal)
    Tablet / gel cap: Not effective (oral)
    Gel: Not effective (buccal and anal)
    IV formula: Effective (intravenous) Not effective (intraperitoneal)

Outcomes

  • As part of the most recent Agricultural Competitiveness White Paper funding, the safety and efficacy testing of the glovebox formulation and intraperitoneal administration pathway did not demonstrate that the product would be effective in reducing PAPP toxicosis in time to fully revive the affected animal and would be, at best, a first aid treatment. The volume of antidote that needed to be injected was quite large and would not have been suitable as a glovebox product even if it had been effective.
  • As such the antidote is still only available as an intravenous administration by a veterinary practitioner. The Australian Veterinary Association has released a co-branded fact sheet detailing best practice for vets for the intravenous administration of the already developed antidote to PAPP toxicosis.
  • This project has reached a point of development where it appears further continuation is not warranted on technical grounds.

Project team

Dr Tony Buckmaster

Centre for Invasive Species Solutions

Project partners

This project received funding from the Australian Government Department of Agriculture, Fisheries & Forestry.