Blue Healer Glovebox Antidote


June 2016 saw the launch of two new baits for wild dog and fox control containing the PAPP toxin. One of the positive aspects of the PAPP toxin is that it has an effective antidote if a working or pet dog accidentally eats a bait. However, the only approved methylene blue antidote product needs to be injected intravenously by a registered veterinarian within at least 60 minutes from ingestion.

Since 2007, the Blue-Healer project (funded previously through the Invasive Animals CRC) has evaluated the safety and efficacy of different methylene blue formulations and routes of administration with the goal that owners could treat accidentally poisoned working or pet dogs. This is a very challenging task and no dog owner administered product is approved by the APVMA yet.

However, despite the size of the challenge ahead, researchers are still working on delivering one.

This stage of the Blue Healer project will include testing an administration method that dog owners could use relatively safely and, if that testing
proves successful, to submit a registration application to the APVMA for a new veterinary medicine that dog owners and vets can both use. Despite the challenges with this ongoing research, we hope the greater availability of the antidote will enhance the adoption of PAPP baits into best practice integrated wild dog and fox management programs.



Project Leader

Dr Tony Buckmaster
Project Partners

This project is funded through an external research grant separate to the Centre for Invasive Species Solutions current innovation portfolio

  • Australian Government Department of Agriculture and Water Resources
  • Charles Sturt University


AVA co-branded fact sheet detailing best practice for vets for the intravenous administration of the already developed antidote to PAPP toxicosis 


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